Dr. Thibaud Renault

Profile

Academic positionAssociate Professor, Senior Lecturer, Reader
Research fieldsBiochemistry,Cell Biology,Microbial Ecology and Applied Microbiology
KeywordsSalmonella, Type 3 secretion system, Flagellum, Protein Secretion, Bacterial Therapy

Current contact address

CountryFrance
CityBordeaux
InstitutionLaboratoire ARNA
InstituteInserm, CNRS, Université de Bordeaux

Host during sponsorship

Prof. Dr. Emmanuelle Marie CharpentierMax-Planck-Institut für Infektionsbiologie, Berlin
Prof. Dr. Marc ErhardtAbteilung Molekulare Infektionsbiologie, Helmholtz-Zentrum für Infektionsforschung GmbH, Braunschweig
Prof. Dr. Marc ErhardtInstitut für Biologie, Humboldt-Universität zu Berlin, Berlin
Start of initial sponsorship01/01/2016

Programme(s)

2015Humboldt Research Fellowship Programme for Postdocs

Publications (partial selection)

2026Freyermuth, Chlo{\'e} and Dupuy, Jean-William and Renault, Thibaud T. and Claverol, St{\'e}phane and Raymond, Anne-Aur{\'e}lie and Thinon, Emmanuelle: A {{Chemical Proteomics Method}} to {{Quantify Cysteine S-Acylation}}. In: ACS Chemical Biology, 2026,
2026Gillard, M{\'e}lanie and Renault, Thibaud T. and Innis, C. Axel: {{iTP-seq}}: A Scalable Profiling Workflow to Characterize Bacterial Translation Landscapes in Vitro. In: Nature Protocols, 2026, 1--32
2025Halte, Manuel and Popp, Philipp F. and Hathcock, David and Severn, John and Fischer, Svenja and Goosmann, Christian and Ducret, Adrien and Charpentier, Emmanuelle and Tu, Yuhai and Lauga, Eric and Erhardt, Marc and Renault, Thibaud T.: Bacterial Motility Depends on a Critical Flagellum Length and Energy-Optimized Assembly. In: Proceedings of the National Academy of Sciences, 122, 2025, e2413488122
2024Bhattacharya, Arunima and Renault, Thibaud T. and Innis, C. Axel: The Ribosome as a Small-Molecule Sensor. In: Current Opinion in Microbiology, 77, 2024, 102418
2023Leroy, Elodie C. and Perry, Thomas N. and Renault, Thibaud T. and Innis, C. Axel: Tetracenomycin {{X}} Sequesters Peptidyl-{{tRNA}} during Translation of {{QK}} Motifs. In: Nature Chemical Biology, 19, 2023, 1091--1096
2021Hüsing, Svenja and Halte, Manuel and {van Look}, Ulf and Guse, Alina and G{\'a}lvez, Eric J. C. and Charpentier, Emmanuelle and Blair, David F. and Erhardt, Marc and Renault, Thibaud T.: Control of Membrane Barrier during Bacterial Type-{{III}} Protein Secretion. In: Nature Communications, 12, 2021, 3999
2020Broglia, Laura and L'écrivain, Anne-Laure and Renault, Thibaud T. and Hahnke, Karin and Ahmed-Begrich, Rina and Le Rhun, Anaïs and Charpentier, Emmanuelle: An RNA-seq Based Comparative Approach Reveals the Transcriptome-Wide Interplay between 3'-to-5' exoRNases and RNase Y. In: Nature Communications, 11, 2020, 1587
2020G{\'a}lvez, Eric J. C. and Iljazovic, Aida and Amend, Lena and Lesker, Till Robin and Renault, Thibaud and Thiemann, Sophie and Hao, Lianxu and Roy, Urmi and Gronow, Achim and Charpentier, Emmanuelle and Strowig, Till: Distinct {{Polysaccharide Utilization Determines Interspecies Competition}} between {{Intestinal Prevotella}} Spp. In: Cell Host \& Microbe, 2020,
2019Renault, Thibaud T. and Guse, Alina and Erhardt, Marc: Export {{Mechanisms}} and {{Energy Transduction}} in {{Type-III Secretion Machines}}. In: Current Topics in Microbiology and Immunology, 2019,
2018L{\'e}crivain, Anne-Laure and Rhun, Ana{\"i}s Le and Renault, Thibaud T. and {Ahmed-Begrich}, Rina and Hahnke, Karin and Charpentier, Emmanuelle: In Vivo 3{$\prime$}-to-5{$\prime$} Exoribonuclease Targetomes of {{Streptococcus}} Pyogenes. In: Proceedings of the National Academy of Sciences, 115, 2018, 11814--11819
2017Renault, Thibaud T. and Dejean, Laurent M. and Manon, St{\'e}phen: A Brewing Understanding of the Regulation of {{Bax}} Function by {{Bcl-xL}} and {{Bcl-2}}. In: Mechanisms of Ageing and Development, 161, 2017, 201--210
2017Fabiani, Florian D. and Renault, Thibaud T. and Peters, Britta and Dietsche, Tobias and G{\'a}lvez, Eric J. C. and Guse, Alina and Freier, Karen and Charpentier, Emmanuelle and Strowig, Till and {Franz-Wachtel}, Mirita and Macek, Boris and Wagner, Samuel and Hensel, Michael and Erhardt, Marc: A Flagellum-Specific Chaperone Facilitates Assembly of the Core Type {{III}} Export Apparatus of the Bacterial Flagellum. In: PLoS biology, 15, 2017, e2002267
2017Renault, Thibaud T. and Abraham, Anthony O. and Bergmiller, Tobias and Paradis, Guillaume and Rainville, Simon and Charpentier, Emmanuelle and Guet, C{\u a}lin C. and Tu, Yuhai and Namba, Keiichi and Keener, James P. and Minamino, Tohru and Erhardt, Marc: Bacterial Flagella Grow through an Injection-Diffusion Mechanism. In: eLife, 6, 2017,
2017Ward, Elizabeth and Renault, Thibaud T. and Kim, Eun A. and Erhardt, Marc and Hughes, Kelly T. and Blair, David F.: Type-{{III Secretion Pore Formed}} by {{Flagellar Protein FliP}}. In: Molecular Microbiology, 2017,
2017Paradis, Guillaume and Chevance, Fabienne F. V. and Liou, Willisa and Renault, Thibaud T. and Hughes, Kelly T. and Rainville, Simon and Erhardt, Marc: Variability in Bacterial Flagella Re-Growth Patterns after Breakage. In: Scientific Reports, 7, 2017, 1282
2016Garenne, David and Renault, Thibaud T. and Manon, St{\'e}phen: Bax Mitochondrial Relocation Is Linked to Its Phosphorylation and Its Interaction with {{Bcl-xL}}. In: Microbial Cell (Graz, Austria), 3, 2016, 597--605
2016Renault, Thibaud T. and {Luna-Vargas}, Mark P. A. and Chipuk, Jerry E.: Mouse {{Liver Mitochondria Isolation}}, {{Size Fractionation}}, and {{Real-time MOMP Measurement}}. In: Bio-Protocol, 6, 2016,
2016Simonyan, Lilit and Renault, Thibaud T. and Novais, Maria Jo{\~a}o da Costa and Sousa, Maria Jo{\~a}o and {C{\^o}rte-Real}, Manuela and Camougrand, Nadine and Gonzalez, C{\'e}cile and Manon, St{\'e}phen: Regulation of {{Bax}}/Mitochondria Interaction by {{AKT}}. In: FEBS letters, 590, 2016, 13--21
2015Renault, Thibaud T. and Teijido, Oscar and Missire, Florent and Ganesan, Yogesh Tengarai and Velours, Gis{\`e}le and Arokium, Hubert and Beaumatin, Florian and Llanos, Raul and Athan{\'e}, Axel and Camougrand, Nadine and Priault, Muriel and Antonsson, Bruno and Dejean, Laurent M. and Manon, St{\'e}phen: Bcl-{{xL}} Stimulates {{Bax}} Relocation to Mitochondria and Primes Cells to {{ABT-737}}. In: The International Journal of Biochemistry \& Cell Biology, 64, 2015, 136--146
2015Serasinghe, Madhavika N. and Wieder, Shira Y. and Renault, Thibaud T. and Elkholi, Rana and Asciolla, James J. and Yao, Jonathon L. and Jabado, Omar and Hoehn, Kyle and Kageyama, Yusuke and Sesaki, Hiromi and Chipuk, Jerry E.: Mitochondrial Division Is Requisite to {{RAS-induced}} Transformation and Targeted by Oncogenic {{MAPK}} Pathway Inhibitors. In: Molecular Cell, 57, 2015, 521--536
2015Renault, Thibaud T. and Floros, Konstantinos V. and Elkholi, Rana and Corrigan, Kelly-Ann and Kushnareva, Yulia and Wieder, Shira Y. and Lindtner, Claudia and Serasinghe, Madhavika N. and Asciolla, James J. and Buettner, Christoph and Newmeyer, Donald D. and Chipuk, Jerry E.: Mitochondrial Shape Governs {{BAX-induced}} Membrane Permeabilization and Apoptosis. In: Molecular Cell, 57, 2015, 69--82
2014Renault, Thibaud T. and Elkholi, Rana and Bharti, Archana and Chipuk, Jerry E.: B Cell Lymphoma-2 ({{BCL-2}}) Homology Domain 3 ({{BH3}}) Mimetics Demonstrate Differential Activities Dependent upon the Functional Repertoire of pro- and Anti-Apoptotic {{BCL-2}} Family Proteins. In: The Journal of Biological Chemistry, 289, 2014, 26481--26491
2014Renault, Thibaud T. and Chipuk, Jerry E.: Death upon a Kiss: Mitochondrial Outer Membrane Composition and Organelle Communication Govern Sensitivity to {{BAK}}/{{BAX-dependent}} Apoptosis. In: Chemistry \& Biology, 21, 2014, 114--123
2014Elkholi, Rana and Renault, Thibaud T. and Serasinghe, Madhavika N. and Chipuk, Jerry E.: Putting the Pieces Together: How Is the Mitochondrial Pathway of Apoptosis Regulated in Cancer and Chemotherapy?. In: Cancer & Metabolism, 2, 2014, 16
2013Renault, Thibaud T. and Chipuk, Jerry E.: Getting Away with Murder: How Does the {{BCL-2}} Family of Proteins Kill with Immunity?. In: Annals of the New York Academy of Sciences, 1285, 2013, 59--79
2013Renault, Thibaud T. and Chipuk, Jerry E.: Inter-Organellar Communication with Mitochondria Regulates Both the Intrinsic and Extrinsic Pathways of Apoptosis. In: Communicative \& Integrative Biology, 6, 2013, e22872
2013Renault, Thibaud T. and Teijido, Oscar and Antonsson, Bruno and Dejean, Laurent M. and Manon, St{\'e}phen: Regulation of {{Bax}} Mitochondrial Localization by {{Bcl-2}} and {{Bcl-x}}({{L}}): Keep Your Friends Close but Your Enemies Closer. In: The International Journal of Biochemistry \& Cell Biology, 45, 2013, 64--67
2013Renault, Thibaud T. and Floros, Konstantinos V. and Chipuk, Jerry E.: {{BAK}}/{{BAX}} Activation and Cytochrome c Release Assays Using Isolated Mitochondria. In: Methods (San Diego, Calif.), 61, 2013, 146--155
2012Asciolla, James J. and Renault, Thibaud T. and Chipuk, Jerry E.: Examining BCL-2 Family Function with Large Unilamellar Vesicles. In: Journal of Visualized Experiments: JoVE, 2012,
2012Renault, Thibaud T. and {Grandier-Vazeille}, Xavier and Arokium, Hubert and Velours, Gis{\`e}le and Camougrand, Nadine and Priault, Muriel and Teijido, Oscar and Dejean, Laurent M. and Manon, St{\'e}phen: The Cytosolic Domain of Human {{Tom22}} Modulates Human {{Bax}} Mitochondrial Translocation and Conformation in Yeast. In: FEBS letters, 586, 2012, 116--121
2011Renault, Thibaud T. and Manon, St{\'e}phen: Bax: {{Addressed}} to Kill. In: Biochimie, 93, 2011, 1379--1391